I-BRD9
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1650 | Check With Us |
| 1g | $2500 | Check With Us |
| 5g | $6325 | Check With Us |
: Cat #: V22379 CAS #: 1714146-59-4 Purity ≥ 98%
Description: I-BRD9 is a BRD9 specific inhibitor, identified by scientists at GlaxoSmithKline.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 497.55 |
|---|---|
| Molecular Formula | C22H22F3N3O3S2 |
| CAS No. | 1714146-59-4 |
| SMILES Code | N=C(C(S1)=CC2=C1C(C3=CC=CC(C(F)(F)F)=C3)=CN(CC)C2=O)NC(CC4)CCS4(=O)=O |
| Synonyms | I-BRD9; I-BRD-9; I-BRD 9 |
| Protocol | In Vitro | I-BRD9 (10 μM) displays >625 fold selectivity in binding with endogenous BRD9 against BET family member BRD3 in HUT-78 cell lysate. I-BRD9 (10 μM) has high aqueous solubility (CLND) with 359 μM. I-BRD9 (10 μM) has affinity for BRD9 (TR-FRET), BRD4 BD1 (TR-FRET) and BRD9 NanoBRET with pIC50 values of 7.3 μM, 5.3 μM and 6.8 μM. I-BRD9 (10 μM) has high BRD9 affinity and excellent broader bromodomain selectivity. I-BRD9 (10 μM, 6 h) has a regulation role in cancer and immunology pathways. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0098 mL | 10.0492 mL | 20.0985 mL | 40.1970 mL |
| 5mM | 0.4020 mL | 2.0098 mL | 4.0197 mL | 8.0394 mL |
| 10mM | 0.2010 mL | 1.0049 mL | 2.0098 mL | 4.0197 mL |
| 20mM | 0.1005 mL | 0.5025 mL | 1.0049 mL | 2.0098 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.