Hypericin (SGX301)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$650	Check With Us
500mg	$1050	Check With Us
1g	$1575	Check With Us

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Cat #: V20851 CAS #: 548-04-9 Purity ≥ 99%

Description: Hypericin(also known as SGX301), is a novel, first-in-class photodynamic therapy using a potent photosensitizer, synthetic hypericin, that is topically applied and activated by safe visible fluorescent light.

References: A Kubin, et al. Hypericin--the facts about a controversial agent. Curr Pharm Des. 2005;11(2):233-53.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	504.45
Molecular Formula	C30H16O8
CAS No.	548-04-9

Protocol	In Vitro	Hypericin (0.25-4 μM; 24 h) inhibits the growth of fibroblasts (Fb), melanocytes (Mc), and keratinocytes (Kc)
	In Vivo	Hypericin (Intravenous injection; 10 mg/kg; once) treatment delays tumor growth
	Animal model	18-20 week-old female BALB/c mice injected with CT26 carcinomas
	Dosages	10 mg/kg
	Administration	Intravenous injection; 10 mg/kg; once

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9824 mL	9.9118 mL	19.8236 mL	39.6471 mL
5mM	0.3965 mL	1.9824 mL	3.9647 mL	7.9294 mL
10mM	0.1982 mL	0.9912 mL	1.9824 mL	3.9647 mL
20mM	0.0991 mL	0.4956 mL	0.9912 mL	1.9824 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.