Hydroxyzine 2HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$200	Check With Us
10g	$320	Check With Us
20g	$480	Check With Us

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Cat #: V1243 CAS #: 2192-20-3 Purity ≥ 98%

Description: Hydroxyzine 2HCl (NSC-169188; NSC169188; Arcanax; Neurolax; Orgatrax; Pamoate, Hydroxyzine; Vistaril), the dihydrochloride salt of hydroxyzine, is a potent histamine H1-receptor antagonist and an antihistamine drug used in the treatment of itchiness, anxiety, and nausea.

References: Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20(10): p. 553-63.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	447.83
Molecular Formula	C21H27ClN2O2.2HCl
CAS No.	2192-20-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 90 mg/mL (201 mM)r
	Water: 90 mg/mL (201 mM)r
	Ethanol: <1 mg/mL
Solubility In Vivo	Saline: 30 mg/mL
Synonyms	Hydroxyzine dihydrochloride; NSC 169188; U.C.B 4492; Hydroxyzine hydrochloride; NSC-169188; NSC169188; trade names: Arcanax; Neurolax; Orgatrax; Pamoate, Hydroxyzine; Vistaril;

Protocol	In Vitro	Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2330 mL	11.1650 mL	22.3299 mL	44.6598 mL
5mM	0.4466 mL	2.2330 mL	4.4660 mL	8.9320 mL
10mM	0.2233 mL	1.1165 mL	2.2330 mL	4.4660 mL
20mM	0.1116 mL	0.5582 mL	1.1165 mL	2.2330 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.