This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 10mg | $90 | 3-6 Days |
| 25mg | $140 | 3-6 Days |
| 50mg | $230 | 3-6 Days |
| 100mg | $400 | 3-6 Days |
| 250mg | $570 | 3-6 Days |
: Cat #: V0148 CAS #: 1276110-06-5 Purity ≥ 99%
Description: HS-173 is a novel and potent inhibitor of PI3Kα (phosphatidylinositol 3-kinase) (IC50 = 0.8 nM)that has the potential to be an efficient treatment for liver fibrosis. HS-173 may also have anticancer effects by encouraging apoptosis and repressing angiogenesis. In vitro and in vivo, HS-173 inhibited the PI3K/Akt signaling pathway. By preventing PI3K/Akt signaling, it reduced fibrotic responses like cell proliferation and collagen production. The PI3K signaling pathway was blocked by HS-173, which also had an anti-proliferative effect on cancer cells. Additionally, HS-173 caused apoptosis and a cell cycle arrest at the G(2)/M phase. Additionally, HS-173 reduced the expression of HIF-1 and VEGF, both of which are crucial for angiogenesis. The suppression of tube formation and migration assay in vitro provided evidence of this effect.
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| Molecular Weight (MW) | 422.4570 |
|---|---|
| Molecular Formula | C21H18N4O4S |
| CAS No. | 1276110-06-5 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | HS173; HS 173; HS-173 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3671 mL | 11.8355 mL | 23.6710 mL | 47.3421 mL |
| 5mM | 0.4734 mL | 2.3671 mL | 4.7342 mL | 9.4684 mL |
| 10mM | 0.2367 mL | 1.1836 mL | 2.3671 mL | 4.7342 mL |
| 20mM | 0.1184 mL | 0.5918 mL | 1.1836 mL | 2.3671 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.