HPOB
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $600 | Check With Us |
| 500mg | $999 | Check With Us |
| 1g | $1498 | Check With Us |
: Cat #: V0265 CAS #: 1429651-50-2 Purity ≥ 98%
Description: HPOB is a novel, potent and selective inhibitor of histone deacetylase 6 (HDAC6) inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 314.34 |
|---|---|
| Molecular Formula | C17H18N2O4 |
| CAS No. | 1429651-50-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 62 mg/mL (197.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 38 mg/mL warmed (120.9mM) | |
| Synonyms | HPOB; 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide |
| Protocol | In Vitro | HPOB (8, 16, or 32 μM; 72 hours) inhibits growth, however, not viability, of normal or transformed cells |
|---|---|---|
| In Vivo | HPOB (300 mg/kg; i.p.; daily for 18 days) and SAHA (50 mg/kg) causes suppression of the growth of established CWR22 tumors | |
| Animal model | Nude mice (CWR22 human prostate cancer xenograf) | |
| Dosages | 300 mg/kg | |
| Administration | I.p.; daily for 18 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1813 mL | 15.9063 mL | 31.8127 mL | 63.6254 mL |
| 5mM | 0.6363 mL | 3.1813 mL | 6.3625 mL | 12.7251 mL |
| 10mM | 0.3181 mL | 1.5906 mL | 3.1813 mL | 6.3625 mL |
| 20mM | 0.1591 mL | 0.7953 mL | 1.5906 mL | 3.1813 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.