HPGDS inhibitor 2

This product is for research use only, not for human use. We do not sell to patients.

HPGDS inhibitor 2
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1350Check With Us
500mg$2350Check With Us
1g$3525Check With Us

Cat #: V31708 CAS #: 2101626-26-8 Purity ≥ 99%

Description: HPGDS inhibitor 2 (GSK2894631A) is a novel, potent, highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM.

References: Deaton DN, et al. The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors. Bioorg Med Chem. 2019 Apr 15;27(8):1456-1478.

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Molecular Weight (MW)378.41
Molecular FormulaC20H24F2N2O3
CAS No.2101626-26-8
SMILES CodeO=C(C1=CC2=CC=C(OC(F)F)C=C2N=C1)N[C@H]3CC[C@H](C(C)(O)C)CC3
SynonymsGSK 2894631A; GSK2894631; GSK-2894631; GSK 2894631; GSK2894631A; GSK-2894631A;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6426 mL13.2132 mL26.4264 mL52.8527 mL
5mM0.5285 mL2.6426 mL5.2853 mL10.5705 mL
10mM0.2643 mL1.3213 mL2.6426 mL5.2853 mL
20mM0.1321 mL0.6607 mL1.3213 mL2.6426 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.