Homatropine Bromide (Homatropine hydrobromide)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10g	$160	Check With Us
25g	$280	Check With Us
50g	$420	Check With Us

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Cat #: V1196 CAS #: 51-56-9 Purity ≥ 98%

Description: Homatropine Bromide (Equipin, Isopto Homatropine), the hydrobromide salt of Homatropine, is a potent muscarinic AChR (acetylcholine receptor) antagonist used before eye examinations (i.e. refraction), before and after certain eye surgeries, and for treating certain eye conditions (e.g., uveitis).

References: Cramer, M.B., L.A. Cates, and D.E. Clarke, Rectal absorption of homatropine [14C]methylbromide in the rat. J Pharm Pharmacol, 1978. 30(5): p. 284-6.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	356.25
Molecular Formula	C16H21NO3.HBr
CAS No.	51-56-9
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 71 mg/mL (199.3 mM)rr
	Water: 71 mg/mL (199.3 mM)rr
	Ethanol: <1 mg/mL
SMILES Code	O=C(C(C1=CC=CC=C1)O)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2.Br
Synonyms	Homatropine hydrobromide; Equipin, Isopto Homatropine

Protocol	In Vivo	Homatropine methylbromide (9 mm x 5 mm conical suppository) causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure in rats
	Animal model	Male albino rats
	Dosages	9 mm x 5 mm conical suppository
	Administration	By suppository

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.8070 mL	14.0351 mL	28.0702 mL	56.1404 mL
5mM	0.5614 mL	2.8070 mL	5.6140 mL	11.2281 mL
10mM	0.2807 mL	1.4035 mL	2.8070 mL	5.6140 mL
20mM	0.1404 mL	0.7018 mL	1.4035 mL	2.8070 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.