H3B-120
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $850 | Check With Us |
| 200mg | $1275 | Check With Us |
| 500mg | $2150 | Check With Us |
: Cat #: V39042 CAS #: 2194903-42-7 Purity ≥ 98%
Description: H3B-120 is a novel and potent carbamoyl phosphate synthetase 1 (CPS1) inhibitor.
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- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 372.48 |
|---|---|
| Molecular Formula | C19H24N4O2S |
| CAS No. | 2194903-42-7 |
| SMILES Code | CN(C(N1CCC(C(NC2=NC(C)=CS2)=O)CC1)=O)CC3=CC=CC=C3 |
| Synonyms | H3B-120; H3B 120; H3B120 |
| Protocol | In Vitro | H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays. H3B-120 achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains. H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase). The half-life of H3B-120 is only 40 min. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6847 mL | 13.4235 mL | 26.8471 mL | 53.6942 mL |
| 5mM | 0.5369 mL | 2.6847 mL | 5.3694 mL | 10.7388 mL |
| 10mM | 0.2685 mL | 1.3424 mL | 2.6847 mL | 5.3694 mL |
| 20mM | 0.1342 mL | 0.6712 mL | 1.3424 mL | 2.6847 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.