This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | 3-6 Days |
| 10mg | $220 | 3-6 Days |
| 25mg | $360 | 3-6 Days |
| 50mg | $560 | 3-6 Days |
| 100mg | $770 | 3-6 Days |
| 250mg | $1140 | 3-6 Days |
: Cat #: V3596 CAS #: 1426802-50-7 Purity ≥ 99%
Description: GSK805 (GSK-805) is a novel, potent, and orally bioavailable RORγt inhibitor with the potential to be used for autoimmune encephalomyelitis (EAE). It inhibits RORγγ with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 assay. Structure-activity relationship exploration on the biaryl moiety led to discovery of potent RORγt inhibitors with good oral bioavailability and CNS penetration. GSK805 demonstrated excellent in vivo efficacy in EAE mice dose dependently with once daily oral administration.
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 532.3595 |
|---|---|
| Molecular Formula | C23H18CL2F3NO4S |
| CAS No. | 1426802-50-7 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | RORγt Inverse Agonist II; GSK-805; GSK 805; GSK805; ROR gamma-t-IN-1; |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8784 mL | 9.3921 mL | 18.7843 mL | 37.5686 mL |
| 5mM | 0.3757 mL | 1.8784 mL | 3.7569 mL | 7.5137 mL |
| 10mM | 0.1878 mL | 0.9392 mL | 1.8784 mL | 3.7569 mL |
| 20mM | 0.0939 mL | 0.4696 mL | 0.9392 mL | 1.8784 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.