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| Size | Price | Stock |
|---|---|---|
| 1mg | $210 | In Stock |
| 2mg | $370 | In Stock |
| 5mg | $560 | In Stock |
| 10mg | $820 | In Stock |
| 25mg | $1420 | In Stock |
| 50mg | $2170 | In Stock |
| 100mg | $3400 | In Stock |
: Cat #: V3594 CAS #: 2131798-13-3 Purity ≥ 99%
Description: GSK656 (GSK-3036656 and GSK-070) is a novel and potent antitubercular agent which acts as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC50 of 0.2 μM. There is an urgent need to develop new and safer antitubercular agents that possess a novel mode of action. GSK3036656 (abbreviated as GSK656) shows potent inhibition of Mtb LeuRS (IC50 = 0.20 μM) and in vitro antitubercular activity (Mtb H37Rv MIC = 0.08 μM). Additionally, it is highly selective for the Mtb LeuRS enzyme with IC50 of >300 μM and 132 μM for human mitochondrial LeuRS and human cytoplasmic LeuRS, respectively. In addition, it exhibits remarkable PK profiles and efficacy against Mtb in mouse TB infection models with superior tolerability over initial leads. This compound has been progressed to clinical development for the treatment of tuberculosis.
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| Molecular Weight (MW) | 293.939461231232 |
|---|---|
| Molecular Formula | C10H14BCL2NO4 |
| CAS No. | 2131798-13-3 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Synonyms | GSK3036656; GSK-3036656; GSK 3036656; GSK070; GSK-070; GSK 070; GSK656; GSK-656; GSK 656; GSK656 HCl. GSK656 hydrochloride |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4021 mL | 17.0103 mL | 34.0206 mL | 68.0412 mL |
| 5mM | 0.6804 mL | 3.4021 mL | 6.8041 mL | 13.6082 mL |
| 10mM | 0.3402 mL | 1.7010 mL | 3.4021 mL | 6.8041 mL |
| 20mM | 0.1701 mL | 0.8505 mL | 1.7010 mL | 3.4021 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.