GSK3368715 | CAS 1629013-22-4

GSK3368715

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$850	Check With Us
200mg	$1275	Check With Us
500mg	$2150	Check With Us

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Cat #: V32454 CAS #: 1629013-22-4 Purity ≥ 99%

Description: GSK3368715 (GSK-3368715; EPZ-019997; EPZ019997) is a novel, orally bioactive, and reversible inhibitor of type I PRMTs (protein arginine methyltransferases) with potential antitumor activity.

References: Fedoriw A, et al. Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. Cancer Cell. 2019 Jul 8;36(1):100-114.e25.

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Molecular Weight (MW)	366.54
Molecular Formula	C20H38N4O2
CAS No.	1629013-22-4
SMILES Code	CNCCN(CC1=CNN=C1C2CCC(COCC)(COCC)CC2)C
Synonyms	EPZ-019997; EPZ 019997; GSK3368715 free base; GSK3368715; GSK-3368715; GSK 3368715; EPZ019997;

Protocol	In Vitro	GSK3368715 (EPZ019997) shows 50% or more growth inhibition relative to DMSO-treated cells in the majority of 249 cancer cell lines, representing 12 tumor types.
Protocol	In Vivo	GSK3368715 (EPZ019997) significantly effects on the growth of BxPC3 xenografts at all doses tested, reducing tumor growth by 78% and 97% in the 150- and 300-mg/kg dose groups, respectively.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7282 mL	13.6411 mL	27.2822 mL	54.5643 mL
5mM	0.5456 mL	2.7282 mL	5.4564 mL	10.9129 mL
10mM	0.2728 mL	1.3641 mL	2.7282 mL	5.4564 mL
20mM	0.1364 mL	0.6821 mL	1.3641 mL	2.7282 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.