GSK3326595 (EPZ-015938)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $699 | In Stock |
| 500mg | $1150 | In Stock |
| 1g | $1725 | In Stock |
: Cat #: V3142 CAS #: 1616392-22-3 Purity ≥ 98%
Description: GSK3326595 (EPZ015938) is a novel, potent, orally bioactive, and selective inhibitor of protein arginine methyltransferase 5 (PRMT5).
References: WO 2016022605 A1
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 452.55 |
|---|---|
| Molecular Formula | C24H32N6O3 |
| CAS No. | 1616392-22-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 90 mg/mL (198.8 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: 90 mg/mL (198.8 mM) | |
| Solubility In Vivo | 2.2 mg/mL in 10% DMSO : 40% PEG300 : 5% Tween-80 : 45% saline |
| SMILES Code | O=C(C)N1CCC(NC2=NC=NC(C(NC[C@H](O)CN3CCC(C=CC=C4)=C4C3)=O)=C2)CC1 |
| Synonyms | EPZ-015938; EPZ 015938; EPZ015938; Pemrametostat; GSK3326595; GSK 3326595; GSK-3326595; |
| Protocol | In Vitro | GSK3326595 (EPZ015938), has entered clinical trials for the treatment of solid tumors and non-Hodgkin’s lymphoma. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2097 mL | 11.0485 mL | 22.0970 mL | 44.1940 mL |
| 5mM | 0.4419 mL | 2.2097 mL | 4.4194 mL | 8.8388 mL |
| 10mM | 0.2210 mL | 1.1049 mL | 2.2097 mL | 4.4194 mL |
| 20mM | 0.1105 mL | 0.5524 mL | 1.1049 mL | 2.2097 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.