GSK2795039
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1980 | In Stock |
| 1g | $3200 | In Stock |
| 5g | $8100 | In Stock |
: Cat #: V3562 CAS #: 1415925-18-6 Purity ≥ 98%
Description: GSK2795039 is a novel and potent small molecule NADPH oxidase 2 inhibitor with a mean pIC50 of 6 in different cell-free assays.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 450.56 |
|---|---|
| Molecular Formula | C23H26N6O2S |
| CAS No. | 1415925-18-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=S(C1=NN(C)C=C1)(NC2=C3C(N(C(C)C)C=C3C4=CC5=C(C=C4)CCN5C)=NC=C2)=O |
| Synonyms | GSK-2795039; GSK 2795039; GSK2795039 |
| Protocol | In Vitro | GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells. |
|---|---|---|
| In Vivo | GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2195 mL | 11.0973 mL | 22.1946 mL | 44.3892 mL |
| 5mM | 0.4439 mL | 2.2195 mL | 4.4389 mL | 8.8778 mL |
| 10mM | 0.2219 mL | 1.1097 mL | 2.2195 mL | 4.4389 mL |
| 20mM | 0.1110 mL | 0.5549 mL | 1.1097 mL | 2.2195 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.