GSK2606414 | CAS 1337531-36-8

GSK2606414

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$710	Check With Us
500mg	$999	Check With Us
1g	$1495	Check With Us

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Cat #: V0059 CAS #: 1337531-36-8 Purity ≥ 98%

Description: GSK2606414 is a novel, potent and selective inhibitor of PERK (PRKR-like endoplasmic reticulum kinase or protein kinase R (PKR)-like endoplasmic reticulum kinase) with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.

References: Axten JM, et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulu

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	451.44
Molecular Formula	C24H20F3N5O
CAS No.	1337531-36-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 90 mg/mL (199.36 mM)r
	Water: <1 mg/mL (slightly soluble or insoluble)r
	Ethanol: 19 mg/mL (42.08 mM)
SMILES Code	FC(C1=CC(CC(N2CCC3=C2C=CC(C4=CN(C)C5=NC=NC(N)=C54)=C3)=O)=CC=C1)(F)F
Synonyms	GSK PERK Inhibitor; GSK2606414; GSK-2606414; GSK 2606414;

Protocol	In Vitro	GSK2606414 inhibits PERK activation in cells.
Protocol	In Vivo	GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2151 mL	11.0757 mL	22.1513 mL	44.3027 mL
5mM	0.4430 mL	2.2151 mL	4.4303 mL	8.8605 mL
10mM	0.2215 mL	1.1076 mL	2.2151 mL	4.4303 mL
20mM	0.1108 mL	0.5538 mL	1.1076 mL	2.2151 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.