Home > Signaling Pathways>Epigenetics>DNA Methyltransferase>GSK-3484862
GSK-3484862

This product is for research use only, not for human use. We do not sell to patients.

GSK-3484862
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$750To Be Confirmed
250mg$1250To Be Confirmed
500mg$1875To Be Confirmed
email: [email protected]        [email protected]

Cat #: V37622 CAS #: 2170136-65-7 Purity ≥ 99%

Description: GSK-3484862 (GSK3484862) is a novel, potent and non-covalent Dnmt1 (DNA methyltransferase) inhibitor with potential anticancer activity.

References: Keystone Symposia 2019 - Epigenetics and Human Disease

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)365.45
Molecular FormulaC19H19N5OS
CAS No.2170136-65-7
SynonymsGSK-3484862
ProtocolIn VitroGSK-3484862 (0-10 µM, 6 or 14 days) induces dramatic DNA methylation loss.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7364 mL13.6818 mL27.3635 mL54.7270 mL
5mM0.5473 mL2.7364 mL5.4727 mL10.9454 mL
10mM0.2736 mL1.3682 mL2.7364 mL5.4727 mL
20mM0.1368 mL0.6841 mL1.3682 mL2.7364 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.