GNE-131

This product is for research use only, not for human use. We do not sell to patients.

GNE-131
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$4103-6 Days
10mg$6603-6 Days
25mg$10703-6 Days
50mg$16703-6 Days
email: sales@invivochem.com        sales@invivochem.cn

Cat #: V4549 CAS #: 1629063-81-5 Purity ≥ 99%

Description: GNE-131 is a novel, potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. The sodium channel NaV1.7 has emerged as a promising target for the treatment of pain based on strong genetic validation of its role in nociception. In recent years, a number of aryl and acyl sulfonamides have been reported as potent inhibitors of NaV1.7, with high selectivity over the cardiac isoform NaV1.5. GNE-131 showed excellent potency, good in vitro metabolic stability, and low in vivo clearance in mouse, rat, and dog. GNE-131 also displayed excellent efficacy in a transgenic mouse model of induced pain.

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Molecular Weight (MW)442.574304103851
Molecular FormulaC23H30N4O3S
CAS No.1629063-81-5
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsGNE-131; GNE 131; GNE-131; 1629063-81-5; GNE131; N-[7-(1-adamantylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl]cyclopropanesulfonamide; GNE 131; N-(7-(adamantan-1-ylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)cyclopropanesulfonamide; N-[7-(adamantan-1-ylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl]cyclopropanesulfonamide; CHEMBL4290579; GNE131
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2595 mL11.2975 mL22.5951 mL45.1902 mL
5mM0.4519 mL2.2595 mL4.5190 mL9.0380 mL
10mM0.2260 mL1.1298 mL2.2595 mL4.5190 mL
20mM0.1130 mL0.5649 mL1.1298 mL2.2595 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.