Glumetinib (SCC244)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1120 | Check With Us |
| 500mg | $1820 | Check With Us |
| 1g | $2730 | Check With Us |
: Cat #: V5225 CAS #: 1642581-63-2 Purity ≥ 98%
Description: Glumetinib (SCC244; SCC-244; Gumarontinib) is a novel, potent and highly selective c-Met kinase inhibitor (IC50 = 0.42 nM.) with antitumor activity.
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| Molecular Weight (MW) | 459.48 |
|---|---|
| Molecular Formula | C21H17N9O2S |
| CAS No. | 1642581-63-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=S(N1N=CC2=NC=C(C3=CN(C)N=C3)C=C21)(C4=CN=C5C=CC(C6=CN(C)N=C6)=CN54)=O |
| Synonyms | Glumetinib; SCC244; SC-C244; SCC 244; Gumarontinib |
| Protocol | In Vitro | Glumetinib (0-50 nM; 24 hours) induces G1–S phase cell-cycle arrest in c-Met–addicted human cancer cells. Glumetinib (SCC244) (0-10 nM; 72 hours) elicits selective and profound effects against c-Met–driven cancer cell proliferation. |
|---|---|---|
| In Vivo | Glumetinib shows significant antitumor efficiency in NSCLC and HCC tumor PDX models with MET aberration. Glumetinib (2.5-10 mg/kg; p.o.; once daily for 2-3 weeks) significantly inhibits c-Met–driven tumor growth in cancer CDX models. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1764 mL | 10.8819 mL | 21.7637 mL | 43.5275 mL |
| 5mM | 0.4353 mL | 2.1764 mL | 4.3527 mL | 8.7055 mL |
| 10mM | 0.2176 mL | 1.0882 mL | 2.1764 mL | 4.3527 mL |
| 20mM | 0.1088 mL | 0.5441 mL | 1.0882 mL | 2.1764 mL |
The molarity calculator equation
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The dilution calculator equation
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Step Two: Enter the in vivo formulation
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Method for preparing DMSO master liquid:
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.