Orforglipron (LY3502970; GLP-1 receptor agonist 1)

This product is for research use only, not for human use. We do not sell to patients.

Orforglipron (LY3502970; GLP-1 receptor agonist 1)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$80In Stock
10mg$100In Stock
25mg$190In Stock
50mg$320In Stock
100mg$500In Stock
250mg$730In Stock
500mg$950In Stock
email: [email protected]        [email protected]

Cat #: V31552 CAS #: 2212020-52-3 Purity ≥ 99%

Description: Orforglipron (LY-3502970; OWL-833; GLP-1 receptor agonist 1) is a novel, oral, and non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist potentially for the treatment of type 2 diabetes mellitus and obesity. Glucagon-like peptide-1 receptor (GLP-1R) agonists are efficacious antidiabetic medications that work by enhancing glucose-dependent insulin secretion and improving energy balance. Currently approved GLP-1R agonists are peptide based, and it has proven difficult to obtain small-molecule activators possessing optimal pharmaceutical properties. We report the discovery and mechanism of action of LY3502970 (OWL833), a nonpeptide GLP-1R agonist. LY3502970 is a partial agonist, biased toward G protein activation over β-arrestin recruitment at the GLP-1R. The molecule is highly potent and selective against other class B G protein-coupled receptors (GPCRs) with a pharmacokinetic profile favorable for oral administration. [1]

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Molecular Weight (MW)882
Molecular FormulaC48H48F2N10O5
CAS No.2212020-52-3
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsGLP-1 receptor agonist 1; 2212020-52-3; LY3502970; CHEMBL4446782; LY-3502970; Orforglipron (USAN); ORFORGLIPRON [USAN];
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.1338 mL5.6689 mL11.3379 mL22.6757 mL
5mM0.2268 mL1.1338 mL2.2676 mL4.5351 mL
10mM0.1134 mL0.5669 mL1.1338 mL2.2676 mL
20mM0.0567 mL0.2834 mL0.5669 mL1.1338 mL
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.