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Glesatinib hydrochloride

This product is for research use only, not for human use. We do not sell to patients.

Glesatinib hydrochloride
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1950Check With Us
250mg$3250Check With Us
500mg$4875Check With Us
email: [email protected]        [email protected]

Cat #: V33826 CAS #: 1123838-51-6 Purity ≥ 99%

Description: Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered.

References: Morgillo F, et al. Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer. J Med Chem. 2017 Sep 14;60(17):7447-7458.

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Molecular Weight (MW)656.17
Molecular FormulaC31H28ClF2N5O3S2
CAS No.1123838-51-6
SMILES CodeO=C(NC(NC1=CC=C(OC2=C3C(C=C(C4=NC=C(CNCCOC)C=C4)S3)=NC=C2)C(F)=C1)=S)CC5=CC=C(F)C=C5.[H]Cl
SynonymsGlesatinib HCl; Glesatinib hydrochloride; MGCD265 hydrochloride; MGCD265 hydrochloride; MGCD265 hydrochloride; MGCD265 HCl; MGCD 265 HCl; MGCD-265 HCl;
ProtocolIn VitroGlesatinib hydrochloride has the cytotoxicity to P-gp overexpressing cancer cells KB-C2, SW620/Ad300, HEK293/ABCB1, and their parent cells KB-3-1, SW620, HEK293 cells with the IC50s fell between 5 and 10 μM. Glesatinib hydrochloride (0.01, 0.1, 0.5, 1 μM) significantly increases by several-fold the percentage of apoptotic cells in NSCLC H1299 cells. Glesatinib hydrochloride (MGCD265 hydrochloride; 0.01-5 μM; for 72 hours) results in a dose-dependent inhibition of cancer cell growth and shows the low IC50 value of 0.08 μM on NSCLC H1299 cells.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.5240 mL7.6200 mL15.2400 mL30.4799 mL
5mM0.3048 mL1.5240 mL3.0480 mL6.0960 mL
10mM0.1524 mL0.7620 mL1.5240 mL3.0480 mL
20mM0.0762 mL0.3810 mL0.7620 mL1.5240 mL
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.