GKT136901
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $620 | Check With Us |
| 500mg | $990 | Check With Us |
| 1g | $1485 | Check With Us |
: Cat #: V21614 CAS #: 955272-06-7 Purity ≥ 98%
Description: GKT136901 is a novel and potent NOX1/4 inhibitor acting by blocking tumor angiogenesis through a PPARα mediated mechanism and selective scavenging of peroxynitrite (PON).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 366.80 |
|---|---|
| Molecular Formula | C19H15ClN4O2 |
| CAS No. | 955272-06-7 |
| SMILES Code | O=C1N(C2=CC=CC=C2Cl)NC(C1=C(C)N3CC4=NC=CC=C4)=CC3=O |
| Synonyms | GKT136901; GKT-136901; GKT 136901; NOX Inhibitor IV; |
| Protocol | In Vitro | GKT136901 (10 μM; 30 min) significantly attenuates high-D-glucose-induced increase in O2•− production and in H2O2 generation in MPT cells. |
|---|---|---|
| In Vivo | GKT136901 (30-90 mg/kg; daily p.o. for 16 weeks) has renoprotective effects in a mouse model of Type 2 diabetes. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7263 mL | 13.6314 mL | 27.2628 mL | 54.5256 mL |
| 5mM | 0.5453 mL | 2.7263 mL | 5.4526 mL | 10.9051 mL |
| 10mM | 0.2726 mL | 1.3631 mL | 2.7263 mL | 5.4526 mL |
| 20mM | 0.1363 mL | 0.6816 mL | 1.3631 mL | 2.7263 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
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Concentration(final)
C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.