Geldanamycin

This product is for research use only, not for human use. We do not sell to patients.

Geldanamycin
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$430Check With Us
1g$645Check With Us
5g$1630Check With Us

Cat #: V0891 CAS #: 30562-34-6 Purity ≥ 98%

Description: Geldanamycin (U-29135; NSC-122750; NSC122750; U 29135) is a natural occurring, benzoquinone-based ,19-membered macrocyle ansamycin class of anticancer antibiotic.

References: Tang HB, et al. Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. Sci Rep. 2016 Jul 26;6:30529

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Product Promise

Promise
Molecular Weight (MW)560.64
Molecular FormulaC29H40N2O9
CAS No.30562-34-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 50 mg/mL (89.18 mM)r
Water: <1 mg/mLr
Ethanol: <1 mg/mL
SMILES CodeNC(O[C@@H](/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC1=C2OC)[C@@H](OC)/C=C\C=C(C)\C(NC(C1=O)=CC2=O)=O)=O
SynonymsNSC 122750; U-29135; NSC-122750; NSC122750; U 29135; U29135
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.7837 mL8.9184 mL17.8368 mL35.6735 mL
5mM0.3567 mL1.7837 mL3.5674 mL7.1347 mL
10mM0.1784 mL0.8918 mL1.7837 mL3.5674 mL
20mM0.0892 mL0.4459 mL0.8918 mL1.7837 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.