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Gallopamil HCl (Methoxyverapamil)

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Gallopamil HCl (Methoxyverapamil)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$750To Be Confirmed
250mg$1450To Be Confirmed
500mg$2175To Be Confirmed

Cat #: V40106 CAS #: 16662-46-7 Purity ≥ 99%

Description: Gallopamil HCl (Methoxyverapamil HCl), a methoxy analog of Verapamil, is a a coronary vasodilator and a phenylalkylamine calcium antagonist.

References: Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21.

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Molecular Weight (MW)521.09
Molecular FormulaC₂₈H₄₁ClN₂O₅
CAS No.16662-46-7
SMILES Codec1(OC)c(OC)cc(cc1OC)[C@@](CCC[N@@](CCc1ccc(c(c1)OC)OC)C)(C(C)C)C#N.Cl           
ProtocolIn VivoGallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate
Animal modelMale Wistar rats weighing 290-370 g
Dosages0.2 mg/kg
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.9191 mL9.5953 mL19.1905 mL38.3811 mL
5mM0.3838 mL1.9191 mL3.8381 mL7.6762 mL
10mM0.1919 mL0.9595 mL1.9191 mL3.8381 mL
20mM0.0960 mL0.4798 mL0.9595 mL1.9191 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.