Galeterone
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $950 | Check With Us |
| 1g | $1400 | Check With Us |
| 5g | $3545 | Check With Us |
: Cat #: V0811 CAS #: 851983-85-2 Purity ≥ 98%
Description: Galeterone (formerly known as NX 41765; TOK001; VN/124-1; NX-41765; VN-1241; TOK-001) is a novel, potent and selective, orally bioavailable CYP17 lyase inhibitor and androgen receptor (AR) antagonist with potential anticancer activity.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 388.55 |
|---|---|
| Molecular Formula | C26H32N2O |
| CAS No. | 851983-85-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 24 mg/mL (61.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 40 mg/mL (102.9 mM) | |
| Solubility In Vivo | 0.5% hydroxyethyl cellulose: 30 mg/mL |
| SMILES Code | O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)C(N5C=NC6=CC=CC=C56)=CC[C@@]4([H])[C@]3([H])CC=C2C1 |
| Synonyms | Galeterone; NX41765; NX 41765; TOK001; NX-41765; VN 1241; TOK-001; TOK 001; VN-1241; VN-1241 |
| Protocol | In Vitro | Galeterone (TOK-001) affords strong CYP17 lyase inhibition, with IC50 of 47 nM. |
|---|---|---|
| In Vivo | Mice inoculated with LAPC-4 tumors are treated subcutaneously with 0.15 mmol/kg of Galeterone (TOK-001) twice daily. Mice treated with TOK-001 have smaller average tumor volume on day 31 when compared to control (p= 0.0001). Galeterone (TOK-001) treatment also significantly reduces the growth rate of tumor growth compared to control (p<0.0001). Upon excision, final tumor weights are also significantly reduced in animals treated with Galeterone (TOK-001) compared to animals treated with control, and castration (p<0.05). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5737 mL | 12.8684 mL | 25.7367 mL | 51.4734 mL |
| 5mM | 0.5147 mL | 2.5737 mL | 5.1473 mL | 10.2947 mL |
| 10mM | 0.2574 mL | 1.2868 mL | 2.5737 mL | 5.1473 mL |
| 20mM | 0.1287 mL | 0.6434 mL | 1.2868 mL | 2.5737 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.