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Fumonisin B1

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Fumonisin B1
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Cat #: V5195 CAS #: 116355-83-0 Purity ≥ 98%

Description: Fumonisin B1 (HSDB7077; RT-013063; HSDB-7077; RT013063) is a naturally occuring mycotoxin/fungal metabolite isolated from Fusarium moniliforme. It acs as a novel and potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) which disrupts de novo sphingolipid biosynthesis.

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CAS No.116355-83-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
ProtocolIn VitroFumonisin B1 alters the gene expression and signal transduction pathways in monkey kidney cells[3]. Fumonisin B1 increases the initial disruption of sphingolipid metabolism and the accumulation of sphinganine in LLC-PK1 kidney cells, causes DNA damage of apoptotic type in rat astrocytes[3].
In VivoAdult male C57BL/6 mice were injected with FB1 (fumonisin B1) (8 mg/kg, i.p.) or its vehicle and 30 min thereafter received with a low dose of the classical convulsant pentylenetetrazol (PTZ, 30 mg/kg, i.p.) or its vehicle. After behavioral evaluation the cerebral cortex and the hippocampus were collected for analysis of Na(+),K(+)-ATPase activity, mitochondrial membrane potential (ΔΨm) and mitochondrial complex I and II activities. FB1 reduced the latency for PTZ-induced myoclonic jerks and increased the number of these events. Altogether, present results indicate that FB1 causes brain hyperexcitability in vivo, and that mitochondrial dysfunction may represent a potential underlying mechanism. [4]
These protocols are for reference only. InvivoChem does not independently validate these methods.
Quality Control Documentation
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Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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