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| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | 3-6 Days |
| 10mg | $125 | 3-6 Days |
| 25mg | $179 | 3-6 Days |
| 50mg | $299 | 3-6 Days |
| 100mg | $515 | 3-6 Days |
| 250mg | $980 | 3-6 Days |
| 500mg | $1420 | 3-6 Days |
: Cat #: V1930 CAS #: 957485-64-2 Purity ≥ 98%
Description: FPH2 (also known as BRD-9424) is able to promote differentiation of iPS-derived hepatocytes. In vitro, FPH2 induced functional proliferation of hepatocytes and might be useful for expanding mature human primary hepatocytes. In human primary hepatocytes, FPH2 increased the number of nuclei undergoing mitosis and hepatocyte nuclei count in a concentration dependent way. Also, FPH2 (40 μM) increased the area of hepatocyte colonies with more hepatocytes and Ki67-positive nuclei, which exhibited hepatocyte nuclear morphologies. In primary human hepatocytes from six additional cell sources, FPH2 increased hepatocytes expansion. FPH2 increased hepatocyte at a rate that is consistent with liver regeneration kinetics in vivo.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 353.83 |
|---|---|
| Molecular Formula | C14H16ClN5O2S |
| CAS No. | 957485-64-2 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 70 mg/mL (197.8 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Synonyms | FPH2, FPH-2, FPH 2; BRD-9424, BRD9424, BRD 9424 |
| Protocol | In Vitro | In vitro activity: FPH2 induces functional proliferation of hepatocytes in vitro, and thus expands mature human primary hepatocytes. FPH2 may lead to the development of new therapeutics for liver diseases. Cell Assay: FPH2 (BRD-9424) is an inducer of proliferation of primary human hepatocytes. In vitro, FPH2 induced functional proliferation of hepatocytes and might be useful for expanding mature human primary hepatocytes. In human primary hepatocytes, FPH2 increased the number of nuclei undergoing mitosis and hepatocyte nuclei count in a concentration dependent way. Also, FPH2 (40 μM) increased the area of hepatocyte colonies with more hepatocytes and Ki67-positive nuclei, which exhibited hepatocyte nuclear morphologies. In primary human hepatocytes from six additional cell sources, FPH2 increased hepatocytes expansion. |
|---|---|---|
| In Vivo | FPH2 increased hepatocyte at a rate that is consistent with liver regeneration kinetics in vivo |
| Related Biological Data |
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| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8262 mL | 14.1311 mL | 28.2622 mL | 56.5243 mL |
| 5mM | 0.5652 mL | 2.8262 mL | 5.6524 mL | 11.3049 mL |
| 10mM | 0.2826 mL | 1.4131 mL | 2.8262 mL | 5.6524 mL |
| 20mM | 0.1413 mL | 0.7066 mL | 1.4131 mL | 2.8262 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.