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| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | 3-6 Days |
| 10mg | $125 | 3-6 Days |
| 25mg | $190 | 3-6 Days |
| 50mg | $330 | 3-6 Days |
| 100mg | $550 | 3-6 Days |
| 250mg | $950 | 3-6 Days |
| 500mg | $1450 | 3-6 Days |
: Cat #: V1943 CAS #: 708219-39-0 Purity ≥ 98%
Description: FPH1 (also known as BRD-6125) is a small molecule that promotes expansion of iPS-derived hepatocytes. FPH1 belongs to the functional proliferation hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. This ability of FPH1 is not dependent on the donors of the hepatocytes. It has been found that FPH1 was active against the primary human hepatocytes from six cell sources of genetically diverse individuals. Besides that, FPH1 can affect the hepatocyte functions with promoting albumin secretion during the differentiation of iPS cells into iHeps. Moreover, treatment of FPH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 388.82 |
|---|---|
| Molecular Formula | C16H15ClF2N2O3S |
| CAS No. | 708219-39-0 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 78 mg/mL (200.6 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Synonyms | FPH-1; BRD-6125; FPH1; BRD6125; FPH 1; BRD 6125 |
| Protocol | In Vitro | In vitro activity: FPH1 induces functional proliferation of hepatocytes in vitro, and causes more pronounced hepatocyte morphologies, including polygonal cell shapes, visible nuclei, and more noticeable bile cannaliculi between hepatocytes. Cell Assay: FPH1 belongs to the functional proliferation hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. This ability of FPH1 is not dependent on the donors of the hepatocytes. It has been found that FPH1 was active against the primary human hepatocytes from six cell sources of genetically diverse individuals. Besides that, FPH1 can affect the hepatocyte functions with promoting albumin secretion during the differentiation of iPS cells into iHeps. Moreover, treatment of FPH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion. |
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| Related Biological Data |
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| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5719 mL | 12.8594 mL | 25.7188 mL | 51.4377 mL |
| 5mM | 0.5144 mL | 2.5719 mL | 5.1438 mL | 10.2875 mL |
| 10mM | 0.2572 mL | 1.2859 mL | 2.5719 mL | 5.1438 mL |
| 20mM | 0.1286 mL | 0.6430 mL | 1.2859 mL | 2.5719 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.