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Fosravuconazole

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Fosravuconazole
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Cat #: V3507 CAS #: 351227-64-0 Purity ≥ 98%

Description: Fosravuconazole (formerly known as E-1224, BEF-1224, and BMS-379224) is an azole-based antifungal agent that can be potentially used for the treatment of fungal infections. It is a prodrug of ravuconazole with improved water solubility. The phosphonooxymethyl ether fosravuconazole was prepared from ravuconazole and bis-tert-butyl chloromethylphosphate. Fosravuconazole was highly soluble in water and converted to the parent in alkaline phosphatase, and also in vivo (rat). Fosravuconazole has proved to be one of the most promising prodrugs of ravuconazole that were tested, and it is currently in clinical evaluation as an intravenous formulation of the broad spectrum antifungal azole, ravuconazole.

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CAS No.351227-64-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.