Fosfomycin calcium (MK-0955)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50g	$250	Check With Us
100g	$450	Check With Us
200g	$675	Check With Us

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Cat #: V18625 CAS #: 26016-98-8 Purity ≥ 98%

Description: Fosfomycin calcium (MK-0955 calcium) is a potent, blood-brain barrier penetrant phosphoenolpyruvate analog produced by Streptomyces and a synthetic broad-spectrum antibiotic with antimicrobial and bactericidal properties.

References: Falagas ME, et al. Fosfomycin. Clin Microbiol Rev. 2016 Apr. 29(2):321-47.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	176.12
Molecular Formula	C3H5CaO4P
CAS No.	26016-98-8
SMILES Code	C[C@H]1[C@@H](P(O)([O-])=O)O1.CC2C(P(O)([O-])=O)O2.[Ca+2]
Synonyms	Calcium fosfomycin; AN-8336; CS-4631; AN8336; CS4631; AN 8336; CS 4631

Protocol	In Vitro	Fosfomycin calcium has bactericidal activity against a variety of gram-negative and gram-positive pathogens, including broad-spectrum production β-Bacteria of lactamase and carbapenemase, and against S. aureus strains with an inhibition rate of 90%. Fosfomycin calcium is an epoxy antibacterial agent. Compared with other antibacterial agents, it acts by inhibiting the early process of cell wall synthesis.
Protocol	In Vivo	Fosfomycin calcium (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	5.6779 mL	28.3897 mL	56.7795 mL	113.5589 mL
5mM	1.1356 mL	5.6779 mL	11.3559 mL	22.7118 mL
10mM	0.5678 mL	2.8390 mL	5.6779 mL	11.3559 mL
20mM	0.2839 mL	1.4195 mL	2.8390 mL	5.6779 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.