Fluticasone propionate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$469	Check With Us
500mg	$699	Check With Us
1g	$1050	Check With Us

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Cat #: V1702 CAS #: 80474-14-2 Purity ≥ 98%

Description: Fluticasone Propionate (formerly CCI187881; CCI 187881; Cutivate, Flixonase, Flixotide, Flonase, Flovent) is a potent and synthetic glucocorticoid medication approved as a nasal spray for use in the treatment of non-allergic and allergic rhinitis.

References: Bryson HM, et al. Intranasal fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in allergic rhinitis. Drugs. 1992;43(5):760-775.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	500.57
Molecular Formula	C25H31F3O5S
CAS No.	80474-14-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (199.8 mM)r
	Water:<1 mg/mLr
	Ethanol: 5 mg/mL (10.0 mM)
Synonyms	CCI-187881; fluticasone Propionate, CCI187881; CCI 187881; Cutivate, Flixonase, Flixotide, Flonase, Flovent

Protocol	In Vitro	Fluticasone propionate inhibits TNFα-induced E-selectin expression, with an IC50 of 1 nM

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9977 mL	9.9886 mL	19.9772 mL	39.9545 mL
5mM	0.3995 mL	1.9977 mL	3.9954 mL	7.9909 mL
10mM	0.1998 mL	0.9989 mL	1.9977 mL	3.9954 mL
20mM	0.0999 mL	0.4994 mL	0.9989 mL	1.9977 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.