Fluorometholone Acetate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$550	Check With Us
5g	$1050	Check With Us
10g	$1575	Check With Us

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Cat #: V1715 CAS #: 3801-06-7 Purity ≥ 98%

Description: Fluorometholone Acetate (formerly NSC47438; NSC-47438; U 17,323; AI 3-52814; Flarex) is a synthetic corticosteroid that has been approved as a medication commonly used as eye drops in the treatment of steroid responsive inflammatory conditions of the eye.

References: A Kupferman, et al. Fluorometholone acetate. A new ophthalmic derivative of fluorometholone. Arch Ophthalmol. 1982 Apr;100(4):640-1.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	418.5
Molecular Formula	C24H31FO5
CAS No.	3801-06-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 84 mg/mL (200.7 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	NSC47438; AI352814; NSC 47438; AI352814; NSC-47438; U 17,323; AI 3-52814; Flarex, Fluorometholone 17-acetate, U-17,323

Protocol	In Vivo	Hourly topical administration of 0.1% Fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis in New Zealand albino rabbits (1.5-2.0 kg). Fluorometholone acetate (0.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3895 mL	11.9474 mL	23.8949 mL	47.7897 mL
5mM	0.4779 mL	2.3895 mL	4.7790 mL	9.5579 mL
10mM	0.2389 mL	1.1947 mL	2.3895 mL	4.7790 mL
20mM	0.1195 mL	0.5974 mL	1.1947 mL	2.3895 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.