Fluconazole (UK49858)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10g	$750	Check With Us
25g	$1350	Check With Us
50g	$2025	Check With Us

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Cat #: V0806 CAS #: 86386-73-4 Purity ≥ 98%

Description: Fluconazole (Diflucan, UK-49858; UK 49858; Triflucan, Elazor, Biozolene) is a novel, potent, and orally bioavailable triazole-based antifungal drug that works by inhibiting fungal lanosterol 14 alpha-demethylase-dependent biosynthesis of ergosterol, which is an essential component of fungal cell membrane.

References: H Yamaguchi, et al. [In vitro activity of fluconazole, a novel bistriazole antifungal agent]. Jpn J Antibiot. 1989 Jan;42(1):1-16.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	306.27
Molecular Formula	C13H12F2N6O
CAS No.	86386-73-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 61 mg/mL (199.2 mM)r
	Water: <1 mg/mLr
	Ethanol: 61 mg/mL (199.2 mM)
SMILES Code	OC(CN1N=CN=C1)(C2=CC=C(F)C=C2F)CN3N=CN=C3
Synonyms	UK 49858; Fluconazole, Diflucan, UK-49858; UK49858; Triflucan, Elazor, Biozolene

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.2651 mL	16.3255 mL	32.6509 mL	65.3019 mL
5mM	0.6530 mL	3.2651 mL	6.5302 mL	13.0604 mL
10mM	0.3265 mL	1.6325 mL	3.2651 mL	6.5302 mL
20mM	0.1633 mL	0.8163 mL	1.6325 mL	3.2651 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.