Flavopiridol (Alvocidib)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $645 | Check With Us |
| 500mg | $1050 | Check With Us |
| 1g | $1575 | Check With Us |
: Cat #: V1535 CAS #: 146426-40-6 Purity ≥ 98%
Description: Flavopiridol (also known as Alvocidib, NSC 649890 HCl; HMR1275; L868275; HMR 1274; NSC649890), a broad spectrum and ATP-competitive inhibitor of CDKs with potential antineoplastic activity.
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| Molecular Weight (MW) | 401.84 |
|---|---|
| Molecular Formula | C21H20ClNO5 |
| CAS No. | 146426-40-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 15 mg/mL (37.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 8 mg/mL (19.9 mM) | |
| Synonyms | NSC 649890 HCl; HMR1275; L868275; HMR 1274; NSC649890; L-868275; NSC-649890; HMR-1275; HMR 1275; L 86-8275; L 868275; HMR-1274; HMR1274; Flavoperidol; Alvocidib |
| Protocol | In Vitro | Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4886 mL | 12.4428 mL | 24.8855 mL | 49.7711 mL |
| 5mM | 0.4977 mL | 2.4886 mL | 4.9771 mL | 9.9542 mL |
| 10mM | 0.2489 mL | 1.2443 mL | 2.4886 mL | 4.9771 mL |
| 20mM | 0.1244 mL | 0.6221 mL | 1.2443 mL | 2.4886 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.