Fingolimod (FTY720) HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $650 | Check With Us |
| 10g | $1050 | Check With Us |
| 20g | $1575 | Check With Us |
: Cat #: V1502 CAS #: 162359-56-0 Purity ≥ 98%
Description: Fingolimod HCl (formerly FTY-720; FTY 720; Gilenia and Gilenya), an FDA approved drug for the treatment of Multiple sclerosis, is a S1P (sphingosine 1-phosphate) antagonist with potential antineoplastic activity.
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- Related Biological Data
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| Molecular Weight (MW) | 343.9 |
|---|---|
| Molecular Formula | C19H33NO2.HCl |
| CAS No. | 162359-56-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 69 mg/mL (200.6 mM)r |
| Water: N/Ar | |
| Ethanol: 69 mg/mL (200.6 mM) | |
| Solubility In Vivo | Saline: 20 mg/mL |
| Synonyms | FTY720; Fingolimod HCl; FTY-720; FTY 720; Trade name: Gilenia and Gilenya. |
| Protocol | In Vivo | Administration of the immunomodulator Fingolimod hydrochloride (0.1 mg/kg i.v.) increases serum S1P, improves impaired systolic contractility and activates the PI3K-pathway in the heart. Administration of Fingolimod hydrochloride (FTY720) causes a significant rise in serum S1P levels in both sham-operated animals and animals challenged with LPS/PepG (P<0.0001) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9078 mL | 14.5391 mL | 29.0782 mL | 58.1564 mL |
| 5mM | 0.5816 mL | 2.9078 mL | 5.8156 mL | 11.6313 mL |
| 10mM | 0.2908 mL | 1.4539 mL | 2.9078 mL | 5.8156 mL |
| 20mM | 0.1454 mL | 0.7270 mL | 1.4539 mL | 2.9078 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.