Fenticonazole Nitrate

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$380	Check With Us
500mg	$580	Check With Us
1g	$870	Check With Us

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Cat #: V2360 CAS #: 73151-29-8 Purity ≥ 98%

Description: Fenticonazole is an azole class of antifungal drug used locally as the nitrate form for the treatment of vulvovaginal candidiasis. It is a 14-α demethylase inhibitor and potentially a glucosamine-6-phosphate synthase inhibitor. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans. Application of fenticonazole nitrate 1 g intravaginal ovules on 2 alternate days is a suitable first-line treatment of vulvovaginitis with acceptable broad-spectrum efficacy against the most commonly involved pathogens and with a low rate of early relapse, reserving antibiotics for patients with treatment failure or relapse of infection .

References: [1]. Rofida Albash, et al. Ultra-deformable liposomes containing terpenes (terpesomes) loaded fenticonazole nitrate for treatment of vaginal candidiasis: Box-Behnken design optimization, comparative ex vivo and in vivo studies. Drug Deliv. 2020 Dec;27(1):1514-1523.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	518.41
Molecular Formula	C24H20Cl2N2OS.HNO3
CAS No.	73151-29-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 104 mg/mL (200.6 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
SMILES Code	ClC1=CC=C(C(OCC2=CC=C(SC3=CC=CC=C3)C=C2)CN4C=C[NH+]=C4)C(Cl)=C1.[O-][N+]([O-])=O
Synonyms	REC 15/1476; REC151476; REC 15 1476; TX 15338; TX15338; TX-15338; Falvin; Lomexin;

Protocol	In Vitro	Fenticonazole is an azole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9290 mL	9.6449 mL	19.2898 mL	38.5795 mL
5mM	0.3858 mL	1.9290 mL	3.8580 mL	7.7159 mL
10mM	0.1929 mL	0.9645 mL	1.9290 mL	3.8580 mL
20mM	0.0964 mL	0.4822 mL	0.9645 mL	1.9290 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.