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Fenclonine (PCPA; CP-10188)

This product is for research use only, not for human use. We do not sell to patients.

Fenclonine (PCPA; CP-10188)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
25g$450To Be Confirmed
50g$750To Be Confirmed
100g$1125To Be Confirmed
email: [email protected]        [email protected]

Cat #: V5275 CAS #: 7424-00-2 Purity ≥ 98%

Description: Fenclonine [para -chlorophenylalanine (PCPA)], is a selective and irreversible inhibitor of tryptophan hydroxylase, which is a rate-limiting enzyme in the biosynthesis of serotonin.

References: M Jouvet. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999 Aug;21(2 Suppl):24S-27S.

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Molecular Weight (MW)199.63
Molecular FormulaC9H10ClNO2
CAS No.7424-00-2
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeC(C(=O)O)(Cc1ccc(cc1)Cl)N
SynonymsDL-3-(4-Chlorophenyl)alanine; Fenclonin; NSC 77370; p-Clorophenylalanine; CP-10,188; CP10,188; CP 10,188; CP-10188; CP10188; CP 10188; Fenclonine;
ProtocolIn VivoFenclonine (intraperitoneal injection; 100 mg/kg; once daily; 3 d) treatment can inhibit Morphine-induced anti-nociceptive activity.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM5.0093 mL25.0463 mL50.0927 mL100.1853 mL
5mM1.0019 mL5.0093 mL10.0185 mL20.0371 mL
10mM0.5009 mL2.5046 mL5.0093 mL10.0185 mL
20mM0.2505 mL1.2523 mL2.5046 mL5.0093 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.