Fasudil (HA-1077) HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $200 | Check With Us |
| 5g | $380 | Check With Us |
| 10g | $570 | Check With Us |
: Cat #: V1344 CAS #: 105628-07-7 Purity ≥ 98%
Description: Fasudil HCl (formerly known as HA1077; HA 1077; HA-1077), the hydrochloride salt of fasudil, is a potent multikinase inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with the potential to be used for the treatment of cerebral vasospasm.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 327.83 |
|---|---|
| Molecular Formula | C14H17N3O2S.HCl |
| CAS No. | 105628-07-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 5 mg/mL (15.3 mM)r |
| Water: 65 mg/mL (198.3 mM)r | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | Saline: 30 mg/mL |
| Synonyms | HA-1077 HCl; HA-1077; Fasudil hydrochloride; HA1077; HA 1077 |
| Protocol | In Vivo | Fasudil Hydrochloride (10 mg/kg; i.v.; 1 h before operation) exhibits protectable effects on cardiovascular disease and reduces the activation of JNK and attenuates mitochondrial-nuclear translocation of AIF under ischemic injury |
|---|---|---|
| Animal model | Myocardial ischemia and reperfusion in rat (250-300 g | |
| Dosages | 10 mg/kg | |
| Administration | Intravenous injection; 1 h before operation |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0504 mL | 15.2518 mL | 30.5036 mL | 61.0072 mL |
| 5mM | 0.6101 mL | 3.0504 mL | 6.1007 mL | 12.2014 mL |
| 10mM | 0.3050 mL | 1.5252 mL | 3.0504 mL | 6.1007 mL |
| 20mM | 0.1525 mL | 0.7626 mL | 1.5252 mL | 3.0504 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.