Ethaselen
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 100mg | $3710 | To Be Confirmed |
| 200mg | $5565 | To Be Confirmed |
| 500mg | $9390 | To Be Confirmed |
: Cat #: V14821 CAS #: 217798-39-5 Purity ≥ 99%
Description: Ethaselen (BBSKE) is a novel, oral and potent organoselenium-based inhibitor of thioredoxin reductase (TrxR) with potential anticancer activity.
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| Molecular Weight (MW) | 422.20 |
|---|---|
| Molecular Formula | C16H12N2O2Se2 |
| CAS No. | 217798-39-5 |
| SMILES Code | O=C1N(CCN2[Se]C3=CC=CC=C3C2=O)[Se]C4=CC=CC=C14 |
| Synonyms | Ethaselen; EB; BBSKE |
| Protocol | In Vitro | Ethaselen (5-10 μM; 12, 24 hours) causes a clear concentration-dependent increase in ROS levels in A549 cells. Ethaselen (2.5-50 μM; 1-24 hours) causes intracellular Trx oxidation in A549 cells. Ethaselen (2.5-10 μM; 12, 24 hours) has no effect on the protein amounts of TrxR1 and Trx. The mRNA level of TrxR1 does not show significant alteration in Ethaselen-treated A549 cells. Ethaselen inhibits the intracellular TrxR1 activity in a concentration- and time-dependent manner, with IC50 values of 4.2 and 2 μM for 12- and 24-h treatments, respectively. Ethaselen (2.5-10 μM; 12, 24 hours) suppresses A549 cell viability in a both concentration- and time-dependent manner. H1666, which has considerably lower TrxR1 expression level, is less susceptible to 24 h treatment with Ethaselen. The inhibition constants for Ethaselen binding to free enzyme (Ki) and the enzyme-substrate complex (Kis) were determined to be 0.022 and 0.087 μM, respectively. Ethaselen also inhibits mammalian TrxR1 in a time-dependent manner possibly by forming a covalent Se-S bond with Cys497 of Trx. |
|---|---|---|
| In Vivo | Ethaselen (BBSKE; 36-108 mg/kg/day; PO; for 10 days) shows increased inhibition of tumor growth in a dose-independent manner. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3685 mL | 11.8427 mL | 23.6855 mL | 47.3709 mL |
| 5mM | 0.4737 mL | 2.3685 mL | 4.7371 mL | 9.4742 mL |
| 10mM | 0.2369 mL | 1.1843 mL | 2.3685 mL | 4.7371 mL |
| 20mM | 0.1184 mL | 0.5921 mL | 1.1843 mL | 2.3685 mL |
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