ERTUGLIFLOZIN PIDOLATE

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$320	Check With Us
500mg	$520	Check With Us
1g	$780	Check With Us

: [email protected] [email protected]

Cat #: V3907 CAS #: 1210344-83-4 Purity ≥ 98%

Description: Ertugliflozin pidolate (formerly known as also known as PF-04971729; trade name: Steglatro), the pidolate salt of ertugliflozin, is a potent, orally bioavailable and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2)approved in 2017 by FDA for treating type 2 diabetes mellitus.

References: Kalgutkar AS, et al. Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. Drug Metab Dispos. 2011 Sep;39(9):1609-19.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	566.0
Molecular Formula	C27H32ClNO10
CAS No.	1210344-83-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 50 mg/mLr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	CCOc1ccc(Cc2c(Cl)ccc([C@]34OC[C@](O3)([C@H]([C@@H]([C@H]4O)O)O)CO)c2)cc1.OC([C@@H] 5CCC(N5)=O)=O
Synonyms	PF-04971729 pidolate; PF 04971729; PF04971729; PF-04971729-00; Ertugliflozin pidolate; Ertugliflozin L-pyroglutamic acid

Protocol	In Vitro	Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro
Protocol	In Vivo	Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) reveals a concentration-dependent glucosuria after oral administration to rats

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7668 mL	8.8339 mL	17.6678 mL	35.3357 mL
5mM	0.3534 mL	1.7668 mL	3.5336 mL	7.0671 mL
10mM	0.1767 mL	0.8834 mL	1.7668 mL	3.5336 mL
20mM	0.0883 mL	0.4417 mL	0.8834 mL	1.7668 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.