ERTUGLIFLOZIN

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$439	Check With Us
1g	$669	Check With Us
5g	$1805	Check With Us

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Cat #: V3906 CAS #: 1210344-57-2 Purity ≥ 98%

Description: Ertugliflozin (formerly known as PF04971729; PF-04971729; trade name: Steglatro) is an orally bioactive and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2) with hypoglycemic and antidiabetic activity.

References: Mascitti V, et al. Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem. 2011 Apr 28; 54(8):2952-60.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	436.89
Molecular Formula	C22H25ClO7
CAS No.	1210344-57-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 45 mg/mLr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	O[C@@H]1[C@](O2)(CO)CO[C@]2(C3=CC=C(Cl)C(CC4=CC=C(C=C4)OCC)=C3)[C@H](O)[C@H]1O
Synonyms	PF-04971729; PF 04971729; PF04971729; PF-04971729-00

Protocol	In Vitro	Ertugliflozin (PF-04971729) exhibits >2-fold selectivity for SGLT1 inhibition (relative to SGLT2000) in vitro
Protocol	In Vivo	Ertugliflozin (PF-04971729) exhibits concentration-dependent glycosuria after oral administration in rats

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2889 mL	11.4445 mL	22.8891 mL	45.7781 mL
5mM	0.4578 mL	2.2889 mL	4.5778 mL	9.1556 mL
10mM	0.2289 mL	1.1445 mL	2.2889 mL	4.5778 mL
20mM	0.1144 mL	0.5722 mL	1.1445 mL	2.2889 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.