Eprosartan Mesylate (SKF-108566J)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $330 | Check With Us |
| 1g | $500 | Check With Us |
| 5g | $1350 | Check With Us |
: Cat #: V1797 CAS #: 144143-96-4 Purity ≥ 98%
Description: Eprosartan Mesylate (SKF-108566J) is a potent and nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively.
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| Molecular Weight (MW) | 520.62 |
|---|---|
| Molecular Formula | C23H24N2O4S.CH4O3S |
| CAS No. | 144143-96-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 104 mg/mL (199.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 4 mg/mL (7.7 mM) | |
| Synonyms | SKF-108566; SKF108566; SKF 108566; Teveten; Futuran; Navixen; Regulaten; SK and F 108566; |
| Protocol | In Vitro | Eprosartan (SKF-108566J) inhibits [125I]AII binding to human liver membranes (IC50 of 1.7 nM) and to rat mesenteric artery membranes (IC50 of 1.5 nM). In rabbit aortic smooth muscle cells, Eprosartan caused a concentration-dependent inhibition of AII-induced increases in intracellular Ca2+ levels |
|---|---|---|
| In Vivo | In conscious normotensive rats, i.v. administration of Eprosartan (0.01-0.3 mg/kg) produced dose-dependent parallel shifts in the AII pressor dose-response curve. Administration of Eprosartan (3-10 mg/kg) intraduodenally or intragastrically to conscious normotensive rats resulted in a dose-dependent inhibition of the pressor response to AII (250 ng/kg, i.v.). At 10 mg/kg, i.d., significant inhibition of the pressor response to AII was observed for 3 hr |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9208 mL | 9.6039 mL | 19.2079 mL | 38.4157 mL |
| 5mM | 0.3842 mL | 1.9208 mL | 3.8416 mL | 7.6831 mL |
| 10mM | 0.1921 mL | 0.9604 mL | 1.9208 mL | 3.8416 mL |
| 20mM | 0.0960 mL | 0.4802 mL | 0.9604 mL | 1.9208 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.