Eplerenone (Epoxymexrenone; CGP 30083)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $545 | Check With Us |
| 500mg | $900 | Check With Us |
| 1g | $1350 | Check With Us |
: Cat #: V2139 CAS #: 107724-20-9 Purity ≥ 98%
Description: Eplerenone (also known as CGP 30083, Inspra, SC-66110) is a potent and selective mineralocorticoid receptor antagonist with an IC50 of 0.36 μM, it blocks the action of aldosterone, used to control high blood pressure.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 414.49 |
|---|---|
| Molecular Formula | C24H30O6 |
| CAS No. | 107724-20-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 4 mg/mL (9.7 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | C[C@]12CCC(C=C1C[C@@H](C(OC)=O)[C@@H]3[C@]24[C@@H](C[C@@]5(C)[C@H]3CC[C@@]56CCC(O6)=O)O4)=O |
| Synonyms | CGP-30083, SC-66110; CGP30083; CGP 30083; SC 66110; SC66110; Inspra; Selara |
| Protocol | In Vitro | Eplerenone inhibits the human mineralocorticoid receptor with IC50 value of 0.081 μM. |
|---|---|---|
| In Vivo | Eplerenone (oral, 200 mg/kg/day for 3 months) significantly reduces oxidative stress and atherosclerosis progression in atherosclerotic apolipoprotein edeficient (EO) mic. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4126 mL | 12.0630 mL | 24.1260 mL | 48.2521 mL |
| 5mM | 0.4825 mL | 2.4126 mL | 4.8252 mL | 9.6504 mL |
| 10mM | 0.2413 mL | 1.2063 mL | 2.4126 mL | 4.8252 mL |
| 20mM | 0.1206 mL | 0.6032 mL | 1.2063 mL | 2.4126 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.