(-)-Epigallocatechin Gallate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $480 | Check With Us |
| 10g | $850 | Check With Us |
| 20g | $1275 | Check With Us |
: Cat #: V1974 CAS #: 989-51-5 Purity ≥ 98%
Description: (-)-Epigallocatechin Gallate (also known as EGCG; epigallocatechin-3-gallate) is a naturally occurring catechin extractied from green tea, which shows multiple bioactivity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 458.37 |
|---|---|
| Molecular Formula | C22H18O11 |
| CAS No. | 989-51-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 72 mg/mL (157.1 mM)r |
| Water:23 mg/mL (50.2 mM)r | |
| Ethanol: 83 mg/mL (181.1 mM) | |
| SMILES Code | O=C(O[C@H]1[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=C(C(O)=CC(O)=C3)C1)C4=CC(O)=C(O)C(O)=C4 |
| Synonyms | EGCG; Epigallocatechol Gallate |
| Protocol | In Vitro | (-)-Epigallocatechin Gallate (10-60 μM, 12 h) reduces cell motility and migration. (-)-Epigallocatechin Gallate (10-60 μM, 0-24 h) reduces cyclin D1 and phosphorylation of AKT and ERK1/2, and increases p21 and p53 expression. (-)-Epigallocatechin Gallate (EGCG, 10-60 μM) inhibits the growth of FB-2 and WRO cells in a dose-dependent manner. |
|---|---|---|
| In Vivo | (-)-Epigallocatechin Gallate (Intragastrical administration, 5-20 mg/kg, once daily for 14 days, orthotopic transplant model) decreases tumors growth. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1816 mL | 10.9082 mL | 21.8164 mL | 43.6329 mL |
| 5mM | 0.4363 mL | 2.1816 mL | 4.3633 mL | 8.7266 mL |
| 10mM | 0.2182 mL | 1.0908 mL | 2.1816 mL | 4.3633 mL |
| 20mM | 0.1091 mL | 0.5454 mL | 1.0908 mL | 2.1816 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.