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| Size | Price | Stock |
|---|---|---|
| 25mg | $100 | In Stock |
| 50mg | $140 | In Stock |
| 100mg | $230 | In Stock |
| 250mg | $340 | In Stock |
| 500mg | $540 | In Stock |
| 1g | $730 | In Stock |
: Cat #: V0942 CAS #: 1204669-58-8 Purity ≥ 99%
Description: Epacadostat (formerly INCB024360; IDO-IN-1; INCB-024360; INCB-24360; INCB24360) is an orally bioavailable, potent and selective IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with potential immunomodulating and antitumor activity. In inhibits IDO1 with an IC50 of 10 nM. By inhibiting IDO1 in tumor cells. Epacadostat increases and restores the proliferation and activation of various immune cells such as dendritic cells, NK cells, T-cells. Epacadostat was under investigation in a phase 3 clinical trial. But according to the results presented at the 2018 ASCO Annual Meeting, in patients with unresectable or metastatic melanoma, adding epacadostat to pembrolizumab (Keytruda) did not result in greater clinical benefit over pembrolizumab alone, according to data from the phase III ECHO-301/KEYNOTE-252 study.
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| Molecular Weight (MW) | 438.23 |
|---|---|
| Molecular Formula | C11H13BrFN7O4S |
| CAS No. | 1204669-58-8 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | INCB14943-analog; INCB-14943-analog; INCB 14943-analog; INCB024360 or INCB24360; Epacadostat-analog; IDO-IN-1;INCB 024360; INCB-024360; INCB-24360; IDO inhibitor 1; 1204669-37-3; INCB-024360; INCB 024360; Epacadostat (INCB024360); (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboxamidine; INCB 24360; |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2819 mL | 11.4095 mL | 22.8191 mL | 45.6381 mL |
| 5mM | 0.4564 mL | 2.2819 mL | 4.5638 mL | 9.1276 mL |
| 10mM | 0.2282 mL | 1.1410 mL | 2.2819 mL | 4.5638 mL |
| 20mM | 0.1141 mL | 0.5705 mL | 1.1410 mL | 2.2819 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.