ent-Tadalafil

This product is for research use only, not for human use. We do not sell to patients.

ent-Tadalafil
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1850Check With Us
200mg$2775Check With Us
500mg$4680Check With Us

Cat #: V40090 CAS #: 629652-72-8 Purity ≥ 99%

Description: ent-Tadalafil (ent-IC-351) is a cis-enantiomer and an impurity of Tadalafil, which is an inhibitor of PDE5/phosphodiesterase 5 approved as an oral drug for treating erectile dysfunction (ED).

References: Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.J Med Chem. 2003 Oct 9;46(21):4533-42.

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Molecular Weight (MW)389.40
Molecular FormulaC22H19N3O4
CAS No.629652-72-8
Synonymsent-IC-351; ent-IC351; ent-Tadalafil; ent Tadala
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.5681 mL12.8403 mL25.6805 mL51.3611 mL
5mM0.5136 mL2.5681 mL5.1361 mL10.2722 mL
10mM0.2568 mL1.2840 mL2.5681 mL5.1361 mL
20mM0.1284 mL0.6420 mL1.2840 mL2.5681 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.