Emodepside | CAS 155030-63-0

Emodepside

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1250	Check With Us
250mg	$1950	Check With Us
500mg	$2925	Check With Us

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Cat #: V4219 CAS #: 155030-63-0 Purity ≥ 98%

Description: Emodepside (also known as BAY 44-4400 and PF 1022-221) is a novel and potent cyclooctadepsipeptide with broad-spectrum anthelmintic activity.

References: Harder A, et al. Mechanisms of action of emodepside. Parasitol Res. 2005 Oct;97 Suppl 1:S1-10.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1119.39
Molecular Formula	C60H90N6O14
CAS No.	155030-63-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=C([C@H](CC(C)C)N(C)C([C@@H](C)OC([C@H](CC(C)C)N(C)C([C@@H](CC1=CC=C(N2CCOCC2)C=C1)OC([C@H](CC(C)C)N(C)C([C@@H](C)OC([C@H](CC(C)C)N3C)=O)=O)=O)=O)=O)=O)O[C@H](CC4=CC=C(N5CCOCC5)C=C4)C3=O
Synonyms	Emodepside; BAY 44-4400; BAY44-4400; BAY-44-4400; BAY444400; BAY-444400; BAY 444400;

Protocol	In Vitro	Emodepside is a semisynthetic derivative of PF1022A, which contains a morpholine attached in para position at each of both D-phenyllactic acids. Emodepside is efficacious against a variety of gastrointestinal nematodes. Emodepside binds to a presynaptic latrophilin receptor in nematodes.
Protocol	In Vivo	Emodepside interferes with signaling at the neuromuscular junction on the body-wall muscles, pharynx and egg-laying muscles and thus inhibits three important physiological functions: locomotion, feeding and reproduction.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.8933 mL	4.4667 mL	8.9334 mL	17.8669 mL
5mM	0.1787 mL	0.8933 mL	1.7867 mL	3.5734 mL
10mM	0.0893 mL	0.4467 mL	0.8933 mL	1.7867 mL
20mM	0.0447 mL	0.2233 mL	0.4467 mL	0.8933 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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