EMD534085
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1580 | Check With Us |
| 500mg | $2500 | Check With Us |
| 1g | $3750 | Check With Us |
: Cat #: V20498 CAS #: 858668-07-2 Purity ≥ 98%
Description: EMD534085 (EMD-534085) is a mitotic kinesin inhibitor (IC50 = 8 nM) currently in clinical development for cancer treatment.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
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| Molecular Weight (MW) | 476.53 |
|---|---|
| Molecular Formula | C25H31F3N4O2 |
| CAS No. | 858668-07-2 |
| Protocol | In Vitro | EMD 534085 does not inhibit any other tested kinesins (BimC, CEN-PE, Chromokinesin, KHC, KIF3C, KIFC3, MKLP-1, and MCAK) at 1 μM or 10 μM concentration, showing selectively over kinesin-5. EMD 534085 binds to the allosteric pocket of kinesin-5 |
|---|---|---|
| In Vivo | In a low dose PK of EMD 534085 in mice the clearance is 1.8 L/h/kg on average, the volume of distribution is 7.4 L/kg and the half life around 2.5 h. The bioavailability in high dose experiments (>10 mg/kg) is always above 50% in mice. Intraperitonal administration of EMD 534085 enables significant systemic exposure in mice leading to a significant tumor growth reduction without toxic side effects |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0985 mL | 10.4925 mL | 20.9850 mL | 41.9701 mL |
| 5mM | 0.4197 mL | 2.0985 mL | 4.1970 mL | 8.3940 mL |
| 10mM | 0.2099 mL | 1.0493 mL | 2.0985 mL | 4.1970 mL |
| 20mM | 0.1049 mL | 0.5246 mL | 1.0493 mL | 2.0985 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.