Ellipticine HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $960 | Check With Us |
| 500mg | $1350 | Check With Us |
| 1g | $2025 | Check With Us |
: Cat #: V3829 CAS #: 5081-48-1 Purity ≥ 98%
Description: Ellipticine HCl, originally identified as a natural product, is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are dictated by activation with cytochrome P450 (CYP).
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 282.77 |
|---|---|
| Molecular Formula | C₁₇H₁₅ClN₂ |
| CAS No. | 5081-48-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 5.8 mg/mLr |
| Water: < 1mg/mLr | |
| Ethanol: < 1mg/mL | |
| Synonyms | Elliptecine HCl; ellipticine; Elliptisine hydrochloride; CCG-36483 hydrochloride; CCG36483 HCl; CCG 36483; NSC 71795; NSC71795 HCl; NSC-71795; DB-052047 HCl; K00071 HCl; LP00531 HCl; LS-133282 HCl; TCMDC-125546 HCl VZ29809; |
| Protocol | In Vivo | Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5364 mL | 17.6822 mL | 35.3644 mL | 70.7289 mL |
| 5mM | 0.7073 mL | 3.5364 mL | 7.0729 mL | 14.1458 mL |
| 10mM | 0.3536 mL | 1.7682 mL | 3.5364 mL | 7.0729 mL |
| 20mM | 0.1768 mL | 0.8841 mL | 1.7682 mL | 3.5364 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.