Elimusertib (BAY-1895344) HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $480 | Check With Us |
| 100mg | $750 | Check With Us |
| 200mg | $1125 | Check With Us |
: Cat #: V3122 CAS #: N/A Purity ≥ 98%
Description: Elimusertib (BAY1895344) HCl, the hydrochloride salt of BAY 1895344, is a selective and orally bioavailable ATR (ataxia telangiectasia and Rad3-related) inhibitor with potential antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 411.89 |
|---|---|
| Molecular Formula | C20H22ClN7O |
| CAS No. | N/A |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >80 mg/mLr |
| Water: >80 mg/mLr | |
| Ethanol: >80 mg/mL | |
| Solubility In Vivo | N/A |
| SMILES Code | CN1N=CC=C1C2=C(C=CN=C3C4=CC=NN4)C3=NC(N5[C@H](C)COCC5)=C2.[H]Cl |
| Synonyms | BAY1895344 HCl; BAY-1895344; BAY 1895344. |
| Protocol | In Vitro | Elimusertib hydrochloride reveals high selectivity against other related kinases, such as DNA-PK (IC50: 332 nM), ATM (IC50: 1420 nM), and PI3K (IC50: 3270 nM) |
|---|---|---|
| In Vivo | Elimusertib hydrochloride (50 mg/kg; p.o.; b.i.d.; 3 days on/4 days off; for 11 days) exhibits strong antitumor efficacy in the ATM-mutated SU-DHL-8 (ATM K1964E) human GCB-DLBCL cell line derived xenograft model in mice | |
| Animal model | Female C.B-17 SCID mice, SU-DHL-8 GCB-DLBCL xenograft model | |
| Dosages | 50 mg/kg | |
| Administration | Oral administration, b.i.d., 3 days on/4 days off, for 11 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4278 mL | 12.1392 mL | 24.2783 mL | 48.5567 mL |
| 5mM | 0.4856 mL | 2.4278 mL | 4.8557 mL | 9.7113 mL |
| 10mM | 0.2428 mL | 1.2139 mL | 2.4278 mL | 4.8557 mL |
| 20mM | 0.1214 mL | 0.6070 mL | 1.2139 mL | 2.4278 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.