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Eliglustat (GENZ-112638, Genz 99067, Cerdelga)

This product is for research use only, not for human use. We do not sell to patients.

Eliglustat (GENZ-112638, Genz 99067, Cerdelga)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$750Check With Us
500mg$1000Check With Us
1g$1500Check With Us
email: [email protected]        [email protected]

Cat #: V6861 CAS #: 491833-29-5 Purity ≥ 98%

Description: Eliglustat (GENZ-112638, Genz-99067, GENZ112638, Genz99067, Cerdelga) is a novel, potent, specific and orally bioactive glucocerebroside synthase inhibitor (IC50 = 24 nM) approved by FDA in 2014 for the treatment for Gaucher's disease.

References: McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91(3):259-68.

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Molecular Weight (MW)404.54
Molecular FormulaC23H36N2O4
CAS No.491833-29-5
SMILES CodeCCCCCCCC(N[C@H](CN1CCCC1)[C@@H](C2=CC=C3OCCOC3=C2)O)=O
SynonymsEliglustat tartrate (USAN); eliglustat hemitartrate; Eliglustat; trade name Cerdelga; GENZ112638; GENZ 112638; GENZ-112638; UNIIN0493335P3;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4719 mL12.3597 mL24.7194 mL49.4389 mL
5mM0.4944 mL2.4719 mL4.9439 mL9.8878 mL
10mM0.2472 mL1.2360 mL2.4719 mL4.9439 mL
20mM0.1236 mL0.6180 mL1.2360 mL2.4719 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.