EL102
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1450 | Check With Us |
| 250mg | $2150 | Check With Us |
| 500mg | $3225 | Check With Us |
: Cat #: V3443 CAS #: 1233948-61-2 Purity ≥ 98%
Description: EL102, a novel toluidine sulphonamide, is a novel inhibitor of HIF1α (hypoxia inducible factor) and can also potently inhibit tubulin polymerisation and decreased microtubule stability.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 384.47 |
|---|---|
| Molecular Formula | C19H16N2O3S2 |
| CAS No. | 1233948-61-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | EL102; EL-102; EL 102 |
| Synonyms | C1=CC(C2C=C(C#N)SC=2)=CC(NS(=O)(=O)C2=CC=C(OC)C=C2)=C1C |
| Protocol | In Vitro | EL-102 (0-100 nM; 1 hour) inhibits Hif1α protein expression. EL-102 (5 nM; 0-60 min) inhibits tubulin polymerisation activity. EL-102 (10-100 nM; 24-48 h) affects PARP cleavage in DU145 cells. EL-102 (10-100 nM; 24-72 h) induces cellular apoptosis and affects cell cycle. EL-102 (0-100 nM; 72 h) shows cytotoxicity to prostate cancer cell lines. EL-102 (0-120 nM; 72 h) inhibits prostate cancer cells proliferation in vitro. |
|---|---|---|
| In Vivo | EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6010 mL | 13.0049 mL | 26.0098 mL | 52.0197 mL |
| 5mM | 0.5202 mL | 2.6010 mL | 5.2020 mL | 10.4039 mL |
| 10mM | 0.2601 mL | 1.3005 mL | 2.6010 mL | 5.2020 mL |
| 20mM | 0.1300 mL | 0.6502 mL | 1.3005 mL | 2.6010 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.